In situ iodination and X-ray crystal structure of a foldamer helix bundle.

نویسندگان

  • Gavin William Collie
  • Karolina Pulka-Ziach
  • Gilles Guichard
چکیده

We report here the efficient in situ iodination of tyrosine-type side-chains located within a foldamer helix bundle, permitting structure determination using single-wavelength anomalous diffraction (SAD) methods. We suggest that this simple method may be of use to those engaged in structural foldamer research as a potential solution to the phase problem.

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عنوان ژورنال:
  • Chemical communications

دوره 52 6  شماره 

صفحات  -

تاریخ انتشار 2016